Life Improvement by Future Technologies Center
photo_2023-12-25_15-08-30

Pavel Musienko

  • Team leader
pol-spb@mail.ru
Biography

Current positions:

 

Education and training:

  • Medical Military Academy, St. Petersburg, Russia/Medicine/”Physician (MD)”/2000
  • Pavlov Institute of Physiology, St. Petersburg, Russia/Physiology/Candidate of Science (PhD)/2006
  • Pavlov Institute of Physiology, St. Petersburg, Russia/Medicine/Doctor of Science (D.Sc)/2014

 

Professional appointments:

  1. Junior scientist at the Motor physiology laboratory Pavlov Institute of Physiology, Russian Academy of Sciences (2002- 2005)
  2. Research Associate at the Motor physiology laboratory Pavlov Institute of Physiology, Russian Academy of Sciences (2005- 2015)
  3. Doctor of medical sciences (D.Sc, doctoral dissertation “Spinal-brain stem mechanisms of posture and locomotion integrative control”, defended on May 2014)
  4. Senior researcher, Motor physiology laboratory, Pavlov Institute of Physiology, Russian Academy of Science (2015-2021)
  5. Professor, Head of Neuroprosthetics Lab, Institute of Translational Biomedicine, Saint-Petersburg State University (2015-present)
  6. Head of Neuromodulation Lab, Pavlov Institute of Physiology, Russian Academy of Science (2020-present)
  7. Full Professor, CNBR center, Skoltech, Russia (2022-2023)
  8. Head of Neurobiology department, Sirius University of Science and Technology, Russia (2022-present)
  9. PI of Neurorehabilitation Technology Lab, Life Improvement by Future Technologies Center “LIFT” (2023-present)

 

Research grants principal investigator (PI) experience:

  • PI in Russian foundation of basic research (RFBR) grant 08-04-00688-А, Project title: «Postural control mechanisms in decerebrated and spinalized animals» (2008-2010)
  • PI in Russian foundation of basic research (RFBR) grant 11-04-01669-А, Project title: «Spinal and brain stem mechanisms of posture and locomotion integrative control» (2010-2012)
  • PI in Russian foundation of basic research (RFBR) grant 12-04-33145-MOL-А-VED, Project title: «Investigation of spinal neuronal mechanisms of postural and locomotor control» (2012-2013)
  • PI in Grant of the President of the Russian Federation MK-5684.2012.4, Project title: «Investigation of bioengineering approaches to restore spinal cord functions» (2012-2013)
  • PI in Russian science foundation (RSF) grant 14-15-00788, Project title: «Spinal and supraspinal mechanisms of the somatosensory control of locomotor movement directions in animals and humans.» (2014-2016)
  • PI in Grant of President of Russian Federation (МD-1018.2017.7), Project title: «Electrochemical neuromodulation in the treatment of patients with spinal cord injury» (2017-2018)
  • PI in Russian foundation for basic research grant (RFBR)17-29-01034-OFI-M, Project title: «Spinal mechanisms of skeletal muscle neuroregulation in condition of modeled microgravity» (2017-2019)
  • PI in Russian foundation for basic research grant (RFBR)17-04-01822-А, Project title: «Spinal mechanisms of somatovisceral integration of bladder and locomotor activity» (2017-2019)
  • co-PI in Grant of German Research Foundation (DFG) for International Collaboration, Project title: «Soft Bioelectronic Implants for Exploring Neural Activity in the Spinal Cord» (2018- 2019)
  • co-PI in Grant of National Institutes of Health (NIH) R01 NS100928-01A1, Project title: «Neural mechanisms of locomotion evoked by epidural stimulation of the spinal cord» (2017-2022)
  • PI in Russian foundation for basic research grant (RFBR) 20-015-00568-А, Project title: «Investigation of the neuronal mechanisms of somatosensory stimulation effects to low urinary tract system» (2020-2022)
  • PI in Russian science foundation (RSF) grant 22-15-00092, Project title: «Investigation of the mechanisms of the parkinsonism development and the new treatment approaches based on multisystem neurorehabilitation» (2022-2024)

 

Research interests:

  • Spinal and brainstem mechanisms of the postural and locomotor control
  • The role of serotonin, noradrenaline, dopamine, trace amine and other neuropharmacological systems in regulation of sensorimotor behaviors
  • Structural and functional organization of the spinal neuronal networks responsible for sensorimotor and somatovisceral integration
  • Pathophysiology of spinal cord injuries (SCI)
  • Mechanisms of the Parkinson’s disease development
  • Spinal cord stimulation, Functional Electrical Stimulation
  • Neurorehabilitation interventions to restore the motor and visceral functions after neurological impairments
  • Cortico-spinal neuroprostheses

 

Publication activity

Peer-reviewed publications – 95

Patents – 11

Citations – 6220

H-index – 32

Publications

Selected peer-reviewed publications:

 

  1. Courtine G, Gerasimenko Y, van den Brand R, Yew A, Musienko P, Zhong H, Song B, Ao Y, Ichiyama RM, Lavrov I, Roy RR, Sofroniew MV, Edgerton VR. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. Nature Neuroscience. 2009; 12 (10): 1333-1342. Link
  2. van den Brand R., Heutschi J., Barraud Q., DiGiovanna J., Bartholdi K., Huerlimann M., Friedli L., Vollenweider I., Moraud E.M., Duis S., Dominici N., Micera S., Musienko P., Courtine G. Restoring voluntary control of locomotion after paralyzing spinal cord injury. Science. 2012. 336(6085):1182-1185. Link
  3. Dominici N, Keller U, Vallery H, Friedli L, van den Brand R, Starkey ML, Musienko P, Riener R, Courtine G. Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. Nature Medicine. 2012; 18(7): 1142-1147. Link
  4. Courtine G, van den Brand R, Musienko P. Spinal cord injury: time to move. Lancet. 2011, 377(9781):1896-8. Link
  5. Wenger N, Moraud EM, Raspopovic S, Bonizzato M, DiGiovanna J, Musienko P, Morari M, Micera S, Courtine G. Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury. Science Transl Med. 2014; 6(255): 255ra133. Link
  6. Minev IR*, Musienko P.* et al. Electronic dura mater for long-term multimodal neural interfaces. Science. 2015; 347(6218):159-163.[* contributed equally]. Link
  7. Friedli L, Rosenzweig ES, Barraud Q, Schubert M, Dominici N, Awai L, Nielson JL, Musienko P, Nout-Lomas Y, Zhong H, Zdunowski S, Roy RR, Strand SC, van den Brand R, Havton LA, Beattie MS, Bresnahan JC, Bézard E, Bloch J, Edgerton VR, Ferguson AR, Curt A, Tuszynski MH, Courtine G. Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates. Science Translational Medicine.  2015; 7(302): 302ra134. Link
  8. Wenger N, Moraud EM, Gandar J, Musienko P. et al. Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury. Nature Medicine. 2016; 22 (2):138-145. Link
  9. Capogrosso M, Wagner FB, Gandar J, Moraud EM, Wenger N, Milekovic T, Shkorbatova P, Pavlova N, Musienko P, Bezard E, Bloch J, Courtine G. Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics. Nature Protocols. 2018; 13: 2031-2061. Link
  10. Afanasenkau D, Kalinina D, Lyakhovetskii V, Tondera C, Gorsky O, Moosavi S, Pavlova N, Merkulyeva N, Kalueff A, Minev I, Musienko P. Rapid prototyping of soft bioelectronic implants for use as neuromuscular interfaces. Nature Biomed Eng. 2020; 4:1010–1022. Link

 

Selected Patents:

 

  • Vörös J, Larmagnac A, Courtine G, Musienko P “PDMS-Based Stretchable Multi-Electrode and Chemotrode Array for Epidural and Subdural Neuronal Recording, Electrical Stimulation and Drug Delivery”. Publication Date 22.12.2011. U.S. Patent №20130303873.
  • Courtine G., Musienko P., Barroud Q. “Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord disorders”. Publication Date 7.01.2015. E.U. Patent №20130174477.
  • Minev I.R., Hirsch A, Musienko P, Courtine G, Lacour S.P. “Synthetic skin for recording and modulating physiological activities“. Publication Date 14.07.2016. E.U. Patent №2016110564.

LIFT Center LLC
Address: 121205, Moscow, territory of the Skolkovo Innovation Center, Skolkovo, Moscow.
Skolkovo Innovation Center,
ul. 5 Nobel str.

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